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Iron overload decreases CaV1.3-dependent L-type Ca2+ currents leading to bradycardia, altered electrical conduction, and atrial fibrillation

Activation of protein kinase B/Akt is sufficient to repress the glucocorticoid and cAMP induction of phosphoenolpyruvate carboxykinase gene

Neutralizing antibodies to AMG 966 result in loss of signal in this assay

Decreased availability and accessibility of iron (ferric ions) inhibit the iron-catalyzed Fenton reaction, which is a major pathway of ROS generation

Afalg M, Gner G, Mller SA, Breimann S, Langosch D, Muhle-Goll C, et al